Supercritical Assisted Production of Lutein-Loaded Liposomes and Modelling of Drug Release

In this work, a lipophilic ophthalmic drug, lutein, has been entrapped in liposomes, using supercritical assisted process. Effects of pressure, temperature, and drug to lipid ratio variation were studied on mean diameters lutein encapsulation efficiency. Liposomes with between 153 ± 38 267 56 nm produced, efficiencies 86.5 0.4% 97.8 1.2% obtained. A Scanning Electron Microscope confirmed spherical shape dimensions vesicles. The temperature for the production liposomes showed significant impact retention time double lipidic layer. Lutein release from produced at 35 °C ended almost 4.5 days; whereas, 40 faster 3 then, vesicles obtained 45 released their content only 2 days. Drug raw data well-fitted Weibull model (R2 up 99%).